2-Phenallyl as a versatile protecting group for the asymmetric one-pot three-component synthesis of propargylamines.
نویسندگان
چکیده
2-Phenallyl was found to be a versatile protecting group of primary amines for the asymmetric one-pot three-component synthesis of propargylamines which leads to enantiomeric excess of up to 96%; it can be easily removed with a palladium(0)-catalyzed allylic substitution using 1,3-dimethylbarbituric acid as a nucleophile.
منابع مشابه
Green and efficient synthesis of propargylamines via A3 coupling reaction using a copper (II)–thioamide combination
A one pot green three‐component coupling reaction of aldehyde, phenylacetylene, and amine derivatives in the presence of copper (II)–thioamide combination as a novel and efficient heterogeneous catalyst under solvent–free conditions is reported. The catalyst displayed high activity and afforded the corresponding propargylamines in good to high yields. The key to this procedure was the generatio...
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ورودعنوان ژورنال:
- Chemical communications
دوره 33 شماره
صفحات -
تاریخ انتشار 2005